Amongst the latter, that is those in whom natural expression is denied an outlet, are found some who have ideals of life, and who are above all reproach; their hidden practice may seem quite powerless to break down or injure character, and therefore it may appear quite harmless. But it seems impossible to find any case where health and mind are not affected; for mental despair arises, or confusion or indecision; or else a physical ailment of a nervous kind; or else a state of mind develops which in its turn produces physical disorder. And here we must reflect that modern science has perhaps still to study the effect of emotion on the blood; this seems to be still a somewhat unexplored field in modern medicine.